Hematopoietic stem cell transplantation: contrasting the outcome of transplantations from HLA-identical siblings, partially HLA-mismatched related donors, and HLA-matched unrelated donors.

Hematopoietic Stem Cell Transplantation: Contrasting the outcome of transplantations from HLA-identical siblings, partially HLA-mismatched related and HLA- matched unrelated donors*

HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation.

The National Marrow Donor Program maintains a registry of volunteer donors for patients in need of a hematopoietic stem cell transplantation. Strategies for selecting a partially HLA-mismatched donor vary when a full match cannot be identified. Some transplantation centers limit the selection of mismatched donors to those sharing mismatched antigens within HLA-A and HLA-B cross-reactive groups ...

Effect of HLA mismatch on acute graft-versus-host disease.

HLA matching between donors and recipients is the most important factor associated with acute graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation. With improvements in GVHD prophylaxis and supportive care, transplantations from HLA mismatched donors are performed increasingly frequently, drawing greater attention to the effects of HLA mismatch. In relat...

Allele Frequencies of HLA-A, B and DRB1 among People of Fars Ethnicity Living in Tehran

Background: Human leukocyte antigens (HLA) are polymorphic cell surface proteins. Distribution of HLA alleles vary among different racial and ethnic populations in unrelated stem cell registries. Determination of HLA allele frequencies in different ethnic groups is useful for population genetic analyses. Materials and Methods: Based on data available from the Iranian Stem Cell Donor Registry...

REPORT OF 200 RENAL TRANSPLANTATIONS FROM LIVING DONORS

Two hundred cases of renal transplantation from living donors are reported from Shahid Hashemi Nejad Medical'Center in Iran. There were 127 male and 73 female patients with 67% in the third and fourth decade of life. All patients received grafts from living donors with 1 14 cases of HLA haploidentical, 55 cases of HLA identical matches and 24 unrelated donors. One year patient and graft su...